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Gaining Weight? Glyburide May Be to Blame!

Gaining weight even when you are following everything decently sounds frustrating, right? To me, the struggle is as horrific as losing half of my cookie while dipping it in coffee!

Well, we will discuss that struggle some other day. Today we are here to talk about medicines turning into our worst nightmares.

Author Tips: Eat this ‘super herb’ before 9am to MELT away belly fat☑️

A popular name that comes into the frame while talking about diabetes is Glyburide. But, how is Glyburide connected to weight gain?

To treat type 2 diabetes, doctors often suggest Glyburide. Weight gain is associated with this medicine as a side effect. To know more about Glyburide weight gain, continue reading this article!

Table of Content

Is It Possible to Gain Weight with Glyburide?

Are you a diabetic patient concerned about the increasing scales in your weighing machine? If so, you are not the only person to feel so!

As a patient, you need to know what medicines you are taking. Trust your doctor but also make yourself aware of the consequences that you are going to face.

Glyburide is an oral medicine that people take to treat type 2 diabetes. It helps to control blood sugar levels. People suffering from diabetes are insulin-resistant.

Diabetes creates a condition where the body cannot produce insulin on its own. As the body is insulin resistant, it fails to store sugar. This results in the presence of sugar in the blood.

In such a state, Glyburide helps to balance the glucose level in the body. It makes sure that the pancreas is releasing more insulin to lower the sugar level in the blood.

But while doing so, glyburide makes a person gain weight. The higher levels of insulin and the lower levels of glucose gradually impact the weight of a diabetic patient.

Glyburide is commonly known as sulphonylureas. They can be found in generic drugs on the market. It is a combination drug that one needs to take with other drugs.

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Glyburide and Its Weight Gaining Properties

Doctors prescribe sulfonylureas to control hypoglycemia in type 2 diabetic patients. But, it is widely known to increase weight in many patients.

Glyburide is an oral medicine as we have already come to know. Glyburide which is also known as sulfonylureas can induce weight gain.

This medicine can affect the metabolic rate. It increases insulin levels and as a result weight gain may take place.

Weight gaining is something that none of us would want to experience. Over that, if you face weight gain due to diabetic medications, the situation gets worse.

Sulfonylurea’s weight gain mechanism can heavily impact one’s physical appearance. Glyburide reduces the need for insulin so it is a medicine preferred by many patients.

Finally, we can understand that glyburide causes weight gain so one should also know the consequences of this medicine before taking it continuously.

If your doctor prescribes you Glyburide, you can try some weight loss supplements. Weight loss supplements will help promote your healthy weight.

Glyburide: Side Effects

While taking Glyburide you should know about the side effects of this drug. Glyburide warnings are well-researched so check them out to know what you can face other than weight gain!

Some common side effects include the following:

  • Diarrhea
  • Nausea
  • Upset stomach
  • Dizziness
  • Headache
  • Metallic taste in the mouth
  • Gas or acidity

A few patients might face more severe side effects than average patients. The serious side effects are also mentioned here.

Allergic reaction. Symptoms may include-

  • Skin rash
  • Itching
  • Hives
  • Swelling of your face, lips, or tongue
  • Trouble breathing

Low blood sugar (hypoglycemia). Symptoms may include:

  • Confusion
  • Increased hunger
  • Dizziness
  • Feeling anxious
  • Sweating
  • Shakiness
  • Feeling cold
  • Irritability
  • Headache
  • Blurred vision
  • Faster heart rate
  • Feeling lightheaded
  • Loss of consciousness
  • Falling
  • Unusual weakness

Stomach problems. Symptoms may include:

  • Upset stomach
  • Stomach pain
  • Liver problems. Symptoms may include
  • Dark-colored urine
  • Yellowing of your skin or the whites of your eyes

Flu-like symptoms. Symptoms may include

  • Fever
  • Chills
  • Sore throat

Lactic acidosis. Symptoms may include:

  • Nausea
  • Vomiting
  • Muscle aches
  • Problems breathing
  • Irregular heart rate
  • Unusual bruising

If you are facing the common side effects then do not worry. Take some time and see if your condition worsens. You will be fine after some time on your own.

But, consult a doctor if you face more severe side effects. Without any delay, talk to your doctor to know if you should stop taking this medicine.

Insulin and Weight Gain

Insulin is the most common name that comes to our mind when we hear about diabetes. It is widely taken by diabetic patients to control the glucose level in the blood.

But, we sometimes come to know that insulin can promote weight gain. It is saddening when you take medicine to lower your blood sugar but gain weight instead.

We all know how insulin works, right? But how does insulin cause weight gain? What is the relation between insulin and weight gain?

Well, when you take insulin, the glucose level in the blood drops. This is the diabetes treatment.

But, if you do not maintain your weight and take more calories, your body will receive more glucose than you need. Glucose that is not used may result in weight gain.

Pro Tips: 10 drops of this every morning is melting away belly fat☑️

Ways to Avoid Weight Gain While Taking Insulin

If you are taking insulin, there are some ways to prevent weight gain. To skip unwanted weight gain you can follow the enlisted things

Count calories

It is important to count calories while having food and drinks. Eat limited carbohydrates. Avoid starchy vegetables and sugar-enriched food.

Do not skip meals

Skipping meals is not an option if you are diabetic. Do not cut calories by skipping any of your meals.

A poor diet will lead to sugar drop. One might even fall unconscious if the sugar level drops too much.

Be physically active

A diabetic patient needs to be physically active. Besides walking, perform a moderately intense aerobic activity.

Consult your doctor to know the appropriate exercise and activities that your body can handle. Physical activity and exercise help the body to use insulin more efficiently.

Ask for substitute medicine

A few diabetes medicines that help to regulate blood glucose levels are-

  • Metformin (Fortamet, Glucophage, others)
  • Exenatide (Byetta)
  • Liraglutide (Victoza)
  • Albiglutide (Tarzeum)
  • Dulaglutide (Trulicity)
  • Sitagliptin (Januvia)
  • Saxagliptin (Onglyza)
  • Canagliflozin (Invokana)
  • Dapagliflozin (Farxiga)
  • Empagliflozin (Jardiance)
  • Pramlintide (Symlin)

These are some of the medicines that you can both inject and orally take. You may ask your doctor for these substitutes as an alternative to insulin.

Take insulin as directed

Do not change your insulin dose to prevent weight gain. Take the insulin as prescribed by the doctor.

The risks related to taking a lower dose of insulin might be severe. Your blood sugar levels will rise and may have a serious impact on the body.


This article on “Glyburide weight gain” gives an insight into the impacts that glyburide has on body weight. Though sulfonylureas are important for controlling blood sugar, it can cause some unwanted weight gain.
The field of medicine has undergone huge advancement in this era. Do not get worried and continue taking your prescribed medicines for a better life.

FAQs About Glyburide Weight Gain

Does diabetes medicine cause weight gain?

Researchers have linked several diabetic medications with weight gain. This is a frustrating issue as we are lowering our blood sugar level but gaining weight.

When the cells do not remove the glucose from the blood, the body stores it as fat. As patients take diabetic medications, they might unintentionally absorb more glucose from food.

This might cause weight gain. But, all medicines do not cause weight gain.

Which diabetes do medications cause weight loss?

Medications have improved in recent times. Glucagon-like peptide 1  (GLP 1) agonists are a class of medicine that not only regulates blood sugar but also reduces weight.

Some of the GLP 1 drugs-

  1. Dulaglutide (Trulicity)
  2. Exenatide extended-release (Bydureon)
  3. Exenatide (Byetta)
  4. Semaglutide (Ozempic)
  5. Semaglutide (Rybelsus)
  6. Liraglutide (Victoza)
  7. Lixisenatide (Adlyxin)

Sodium-glucose cotransporter 2 (SGLT-2) inhibitors also fall under the weight-reducing drug.

Does Glucovance cause erectile dysfunction?

Glucovance is the combination of glyburide and metformin HC1. This is an oral tablet for those who do not take insulin regularly.

Metformin can significantly reduce the testosterone level in males. It has an impact on sex drive and also induces erectile dysfunction.

Low testosterone level is one of the main reasons behind erectile dysfunction. So, metformin present in the Glucovance is to blame here!

Does metformin cause weight gain?

Metformin comes with a regular concern and that is weight loss. In most patients this drug results in weight loss.

Though metformin is linked with weight loss, it might sometimes bring no change in some people. Other than weight loss it can cause bloating, heartburn, nausea, and constipation.

Eat this ‘super herb’ before 9am to MELT away belly fat☑️

Thanks for Reading!

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