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Arimistane vs Clomid: Know Your Facts!

Arimistane is an anti-aromatase inhibitor. It is an estrogen blocker and increases testosterone levels in the body. It is prescribed for breast cancer in menopausal women.

On the other hand, Clomid is an ovulatory stimulant. It releases hormones through pituitary glands for ovary stimulation. The medication helps conceive women with ovulatory failure. 

Clomid also results in increased testosterone levels because of pituitary gland hormones. The increased testosterone level is linked with body mass and strength.

These hormone shifts result in increasing muscle mass and reducing fat storage. These effects make it popular among gym-goers and bodybuilders.

So, which one to choose between Arimistane Vs Clomid?

Arimistane vs Clomid, both are anti-estrogen and boost testosterone indirectly. Arimistane formula is prescribed for breast cancer while Clomid is for infertility. Bodybuilders use Arimistane as a prohormone, cycle, and PST. While Clomid for recovery in PST. They have very different modes of action.

Are you still confused? Don’t worry. We will discuss this in detail below. 

Read it till the end to know!

Clomid and Arimistane both are legal if taken for clinical purposes. Both of them are over-the-counter drugs. The hormone shift produced by both of these drugs results in an indirect increase in testosterone. 

Table of Content

Arimistane vs Clomid: How Do These Drugs Work?

Even though they both affect hormone levels, the working mechanism of Arimistane and Clomid is quite different. Let’s understand how they work in our bodies.


Arimistane is a suicide aromatase inhibitor. It permanently blocks the aromatase enzyme. In normal conditions, aromatase converts androgens including testosterone into estrogens. 

The blocking of the enzyme thus reduces estrogen production. Also increases free testosterone. Reduction in cortisol and increase in luteinizing hormone is also observed.


The breast and ovarian cancers grow with estrogen. So blocking it in post-menopause women is an effective treatment.


Clomid comes under the category of ovulatory stimulant. It triggers the release of gonadotropic hormones from the pituitary gland present in the brain. Gonadotropic hormones include LH luteinizing hormone and FSH Follicle-stimulating hormone. 

The LH and FSH stimulate ovulation by the maturation of the ovarian follicle. Hence, used in infertility treatment in case of anovulation.


On the other hand, a high level of LH binds with Leydig cells. Leydig cells produce testosterone. Hence, high LH results in high testosterone.

Arimistane vs. Clomid: Clinical Application

Arimistane and Clomid, despite both affecting estrogen and testosterone levels, have different medical applications. Let’s have a look one by one for which condition each of these drugs is prescribed.


Arimistane can be used for the following conditions:

  • Breast Cancer In Postmenopausal Women: Postmenopausal women do not produce estrogen through ovaries. Hence, it reduces free estrogen to treat it.
  • Gynecomastia In Men: Development of female characteristics in males like breast enlargement. It happens to the imbalance of estrogen and testosterone similar to taking letro and nolva causing gyno. 
  • Off-Label Testosterone Booster:  For weight loss, athletic strength, muscle mass, and sexual problems.


Clomid is mainly used to treat fertility-related issues in female which includes:

  • Infertility: It promotes maturation of egg, ovulation, and hence pregnancy. Taken under physician’s guide and calculated timely coitus.
  • Ovulatory Failure: It regulates ovulation.
  • PCOS Related Infertility: PCOS causes hormonal imbalance. It can affect ovulation. It maintains the hormonal balance for conceiving.

Clomid is not FDA approved for males. But because it increases testosterone, off-label usage is reported.

Arimistane vs. Clomid: Use By Bodybuilders

Arimistane and Clomid both have been observed to be taken by bodybuilders. Let us understand how these medical drugs became popular among them.

Since both of these drugs directly or indirectly result in increasing testosterone levels in the body. Testosterone is the hormone that gives extra benefit to muscle building. Especially to the professionals who do steroid cycles. 

These drugs help in recovering from steroid effects.



Arimistane is used as a prohormone, in cycles as well as PCT (post-cycle therapy). The PCT benefits include reduction of the estrogen level in the body increased during a test cycle. 

Cycles are the periods in which bodybuilders take doses of for example steroids and other supplements. Continue it for a certain period and then take a break which is called post-cycle therapy. 

The drug is popularly described among bodybuilders with the following properties:

  • Testosterone boost
  • Estrogen blocker
  • Increased libido
  • Muscle strength
  • Fat reduction
  • Sexual problems


Clomid is especially used to get rid of the side effects of anabolic steroids. Professional bodybuilders do these cycles with steroids. It results in loss of natural testosterone production, gynecomastia, and sexual problems.

Clomid’s anti-estrogenic properties make it useful for them. It prevents the conversion of steroids into estrogen as well as boosts testosterone. It speeds up the recovery in PCT. Swiftly remove the side effects of steroids.

However, it is always safe to tend to natural ways to boost testosterone levels in the body. As they are the safest option.

Abuse By Athletes

Because of the reasons described above, these drugs are pretty popular among regular bodybuilders.  Many professional athletes also take these supplements to boost their muscles. 

To prevail in an environment of fair competitive competition, certain drugs are banned for athletes. Also, to prevent serious health risks they come with.

World Anti-Doping Agency WADA, has issued a list of such drugs. The usage of both of these drugs is prohibited.

Arimistane vs. Clomid: Side Effects

Let’s understand the general side effects and major health issues caused by Adrimistane vs Clomid


The general side effects of arimistane include the following:

  • Nausea, stomach upset, and vomiting
  • Heat flashes
  • Headache, dizziness, memory loss
  • Eye-sight / vision problems
  • Balance and coordination problems
  • Sleep problems
  • Rashes
  • Stuffy nose

When to Call a Doctor

If you experience serious effects which include:

  • Seizures
  • Fever/chills
  • Fainting
  • Jaundice
  • Slow heart rate


The common side effects of Clomid include:


When to Call a Doctor

In case of allergic reaction which results in swelling of face, tongue, lip, or throat. If you are exhibiting symptoms of ovarian hyperstimulation syndrome (OHSS) like:

  • Nausea, diarrhea, vomiting
  • Bloating, stomach discomfort
  • Little to no urination
  • Difficulty in breathing
  • Slow heart rate
  • Pelvic pain
  • Vision problem
  • Flashes in visions
  • Light sensitivity
  • Vaginal bleeding

Arimistane vs. Clomid: Legality

Clomid and Arimistane both are legal if taken for clinical purposes. Both of them are over-the-counter drugs. The hormone shift produced by both of these drugs results in an indirect increase in testosterone. 

These drugs could be abused by athletes to enhance their performance at the risk of negative health effects. Hence, both of them are prohibited by WADA under the S4 Category of Hormone and Metabolic Modulators.

So, these drugs are legal but not for athletes to enhance their performance. You may take other supplements like test tren anadrol to increase your testosterone level. 

Precautions to Be Taken

Some precautions to be needed while using both the drugs. The precautions are described below.

For Bodybuilders

It should be kept in mind that there are no guidelines for these drugs to be used in bodybuilding. These drugs are not approved by the FDA for usage other than clinical reasons.

Contrary to males, estrogen plays a more important role in female bodies. No wonder it is also known as the female hormone. Female athletes and bodybuilders should especially avoid taking these medications.

Females report osteoporosis and joint disorders for example arthritis, joint pain, and arthrosis upon taking anti-estrogens. It disturbs the regular menses cycle or even leads to amenorrhea.

For Clinical Treatments

Drugs should be started after consultation with doctors. Clomid should not be taken with pregnancy. If you have a history of any of the following Clomid should not be taken:

  • Adrenal or thyroid disorder
  • Ovarian cyst
  • Abnormal vaginal bleeding
  • Liver Disease


Final Verdict

Both of these drugs have different mechanisms of action for the treatment of different conditions. The only common thing is their use by bodybuilders. 

There is not enough scientific evidence to back its use in bodybuilding. No approved guidelines or safety ensured as well. Moreover, the ban on such drugs by WADA also points out that they should be avoided.

However, if you want to reduce the production of estrogen, you can go for Arimistane. But, if you need fertility treatment, Clomid is for you. 


Is it legal for athletes?

No, if it appears in any random test the player would face penalties.

What if the athlete is prescribed these drugs for clinical conditions?

In that case, the players can apply for the Therapeutic use exemption (TUE). 

Is Clomid better than testosterone replacement therapy (TRT)?

Clomid can be used as an alternative to TRT because it has fewer side effects. But consultation with a physician is ideal, so they can choose the ideal treatment for you.


Hope you are now clear about the debate between Arimistane vs Clomid. The use of these supplements and their benefits are explained in this article. 

If you still have more questions to ask, leave your comments in the section below. We will meet again next time. 

Have a healthy life! Stay safe!

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