Hey there! Wholesomealive is reader-supported. We may earn a small commission from affiliate links at no extra cost to you. Your support helps us create great content. Thank you!

What Are The Effects of Taking Ibuprofen and Adderall Together?

Adderall is an FDA-approved drug used to reduce impulsivity and increase focus. Yet, it can interact with other drugs or medicines you take with or after it. Such as Antacids or CYP2D6 inhibitors may interact with Adderall and lead to health risks. 

Anyhow, there are few incidences of Ibuprofen and Adderall interaction. So, can you take painkillers and Adderall together?

As a matter of fact, there are few adverse effects of Tylenol, Ibuprofen, with Adderall. Let’s discover this in-depth!

Table of Content

Can You Take Ibuprofen With Adderall?

Ibuprofen is a non-steroidal, anti-inflammatory drug used to cure fever and pain. Doctors prescribe it to lower menstrual cramps, headaches, and rheumatoid arthritis. 

As for the combination of Adderall and Ibuprofen, it does not lead to drug interactions. Even not with Adderall XR. So, you can take Ibuprofen or Tylenol for headaches or pain while on Adderall. 

However, Ibuprofen is probably not something you take every day like Adderall. Moreover, don’t exceed the recommended dosage. 

Ibuprofen and Adderall Interaction

Although Adderall is a stimulant for the nervous system, Ibuprofen works on it as well. It may result in minor sleepiness, but it isn’t enough to cancel each other out. Like aspirin, it thins the blood and makes it easier to flow faster to avoid pooling.

While no interactions have been reported with this combo drug, this doesn’t mean no reactions are possible. Indeed, side effects can occur if you do not take medicines as a health provider recommends.

Ibuprofen And Adderall

It may lead to stomach upset, nausea, constipation, and headache. However, severe or fatal interactions are rare. But, you can encounter allergic reactions, but it is also a rare case. 

If your doctor has prescribed this drug, remember that they have determined that the benefit outweighs the risk. As a whole, Ibuprofen and amphetamine/dextroamphetamine do not cause side effects in people who take them.

Related to read: Does Ibuprofen Cause Anxiety? 

What Pain Reliever Can I Take With Adderall?

Adderall has no or very few interactions with Analgesics. If you are on Adderall therapy, you can take the following painkillers. As I mentioned before, the lack of evidence of interaction does not mean you do not interact. It is best to talk with a provider before taking Adderall and painkillers:

  • Paracetamol
  • Ibuprofen

Ibuprofen vs Advil While on Adderall

Ibuprofen and Advil are anti-inflammatory and painkillers. It is prescribed for painful periods, migraine, fever, etc. Interestingly, there is no real difference between the two drugs. Moreover, both have no drug interaction with Adderall.

Anyhow, Adderall is considered safe and better than Ibuprofen. Since Ibuprofen does not have enough coating, it may result in an upset stomach. In contrast, Advil has a better coating than Ibuprofen. So, it passes through stomach acid with no adverse effect. 

Ibuprofen VS Advil And Adderall

No doubt, Advil is a little expensive than Ibuprofen, but it works better than Ibuprofen. 

Can You Have Caffeine With Adderall?

As we know, Adderall is a stimulant that boosts neural hormones. Meanwhile, coffee does the same job. So, you must wonder if drinking coffee is safe while on Adderall (mixed amphetamine salts).

Caffeine and Adderall have similar properties; both have the same effect on the body. So, when you combine them, it can be risky. Also, you are at risk of side effects and health problems if you are a regular user of both. 

Adderall with coffee interaction

You may experience side effects from Adderall and caffeine if you drink coffee. Following are the few possible risks: 

  • Sleeplessness
  • Nervousness and confusion
  • Abnormal or rapid heart rate
  • Feeling restless and jittery.
  • Stomach Problems (diarrhea and nausea)
  • Dehydration
  • Dependency (it may require you to take more to achieve results)

Yet, everybody responds in a different way to drug interaction. Thus, you may or may not experience all the effects of taking caffeine with Adderall. 

A small amount of caffeine is not harmful when used with Adderall. Anyhow, there is no standardized amount of caffeine that you can consume safely. 

Thus, considering these uncertainties, it’d be safe not to drink coffee with Adderall. 

Related to read: What Are the Aftereffects of Adderall?

What Medicine Should You Not Take With Adderall?

Adderall may interact with some drugs that can result in mild, serious, or even fatal health risks. A drug interaction may affect how your medication works and  increase your risk. 

This section does not contain all the drugs that can interact with Adderall. But I try to add possible drugs that can result in drug interaction. Anyhow, check with your provider before you stop, start, or change the dosage of a medication. 

  • Don’t take MAO inhibitors. Including methylene blue, isocarboxazid, moclobemide, metaxalone, safinamide, linezolid, selegiline, tranylcypromine, procarbazine, rasagiline, phenelzine.
  • Cough syrups and cold treatment may increase the risk of blood pressure.
  • The use of drugs that can increase serotonin in the body may result in toxicity or serotonin syndrome, usually street drugs such as ecstasy. Moreover, antidepressants such as SSRIs include paroxetine/fluoxetine, SNRIs, e.g, venlafaxine/duloxetine, etc., are harmful while on Adderall. 
  • Also, avoid using dextroamphetamine together with medications that contain lisdexamfetamine.
  • Antacids can increase the absorption of Adderall. 
  • Some thiazides and Acetazolamide increase the amount of Adderall in the blood.
  • A propoxyphene overdose while taking Adderall can result in fatal convulsions.
  • Inhibitors of CYP2D6, such as Wellbutrin, Cymbalta, Paxil, Benadryl, and Prozac, can increase Adderall in blood. Also, it may cause a potential increase in the severity of serotonin syndrome.
  • Tricyclic antidepressants may become stronger with Adderall, increasing the likelihood of side effects.
  • A proton pump inhibitor may affect Adderall’s clinical effect length. So medical providers should monitor people who take these drugs with Adderall.
  • Besides these, Adderall use may also interfere with some laboratory tests and result in false results. 


Can I take aspirin with Adderall?

Yes, you can take aspirin with Adderall or any other stimulant. It does not cause any drug interaction. Moreover, both drugs play their role without any side effects.

Can you take Midol with Adderall?

You can take Midol and Adderall as combo drugs. It does not result in drug interaction. Although it is clinically significant, still, it may result in some risk. Withal, the benefits of the combo drug for relief may outweigh the side effect. 

What vitamins can you not take with Adderall?

You can not take vitamin C with Adderall. In fact, you should avoid fruits containing vitamin C, fortified juice with vitamin C, or even ascorbic acid supplements. It can affect the potency of Adderall.

Is it bad to take Adderall every day?

Indeed, Adderall is safe to use every day on a doctor’s recommendation. Many people are taking the prescribed dosage of Adderall. But, it may cause mild side effects, such as loss of appetite, insomnia, dryness, etc. These effects may go with time. 

Can you mix Adderall and naproxen?

Naproxen is a robust anti-inflammatory painkiller. You can take it with Adderall. Nevertheless, it is best to talk with the doctor. Moreover, don’t overdose on the drug.

Can I take antihistamine with Adderall?

If you are on long-term Adderall, you should avoid encountering an antihistamine. This drug interaction may result in abnormal sedative effects that could be dangerous.

Can You Take Adderall With Tylenol?

Tylenol is used for fever and mild pain. You can take Tylenol with Adderall for sure. Indeed, there is little evidence of Adderall and Tylenol interaction. Yet, it can be good if you consider the doctor’s advice.

Can you take Tums with Adderall?

Tums are gastrointestinal alkalinizing agents. With Adderall, it should be best to avoid antacids and other alkalizing agents. They can interact with the absorption of Adderall in the body. 

What vitamin should you don’t mix with Adderall?

As a whole, taking vitamins does not cause any interaction with Adderall. But, diet and supplements containing ascorbic acid (vitamin C) may lead to side effects. It is gut acidifying that can lower the absorption of the Adderall drug. 


As a whole, Ibuprofen and Adderall usually do not result in any interaction. However, a mild gastric upset or headache can occur. But over dosage or drug abuse may result in some health consequences. 

It is always best to ask your health provider before adding, stopping, or starting any drug while on Adderall. 

Wholesomealive.com -a blog about Healthy Living