Which Foods to Avoid with Trulicity?

The answer is as simple as it can be-none. You need not worry about what food you can eat if you’re diabetic and taking Trulicity. However, moderation is your way of life. There’s no “NO” to any food. Just a little self-discipline will go a long way.

With self-discipline comes self-restraints and control. So, even though none of the food is restricted for you, there are some foods to avoid with trulicity to amplify the effect of the drug. Read further to know more about what not to take when you are on trulicity.

What is trulicity

Trulicity is a non-insulin injectable drug used to control blood glucose levels with a low risk of hypoglycemia. Hypoglycemia is a common drawback for most glucose-reducing drugs but is not the case for trulicity.

Combined with diet and exercise, trulicity can do wonders at treating type 2 diabetes. Additionally, it can reduce the risk of major cardiovascular diseases such as heart attack and stroke. It also aids weight loss.

Trulicity injection is given under the stomach, thigh, or upper arm as muscular areas quickly absorb the injection. You need to inject it only once per week.

How does trulicity work

Trulicity or dulaglutide is a drug that enhances the activity of the GLP-1 receptor, a glucagon-like peptide that is a natural human hormone.

It binds to the receptor that is present in the cells of the pancreas and helps release insulin from the pancreas. Increased activity of the receptor improves glycemic control by-

  • Decreasing glucagon secretion to reduce glucose production by the liver
  • Reducing hunger cramps by slowing gastric emptying
  • Increasing intracellular second messengers such as cAMP leading to glucose-dependent insulin release
  • Stimulating natural production of insulin in the body

Trulicity and diabetes

Diabetes is a chronic ailment that has reached an epidemic proportion among adults and children around the world. It is a disease that doctors often say affects from “the hair bulb to the toe finger”.

foods to avoid with trulicity

There are two types of diabetes you can suffer from. One where your body is not using insulin like it should (type 2 diabetes) and the other when your body is not making insulin or in an insufficient amount (type 1 diabetes).

Nevertheless, is trulicity effective against both types of diabetes?

No. Trulicity is only effective against type 2 diabetes. Treating type 2 diabetes requires the perfect balance of food, exercise, and medication. Trulicity is just making its name in the diabetic treatment field.

Trulicity Complaints (Side Effects)

Common side effects of trulicity include stomach pain, indigestion, diarrhea, loss of appetite, vomiting, and bloating. About 10% of the people taking trulicity complain of feeling “full” or that they are experiencing a sensation similar to that of overeating.

Other complaints include feeling enervated and exhausted. Trulicity fatigue is real. It can make you feel sleepy all day. If you find yourself stuck to your bed 24/7, trulicity is probably not best suited for you.

In the long run, it can cause dulaglutide tolerance which happens from insulin resistance.

Serious side effects include thyroid cancer(boxed warning from the FDA), kidney problems, pancreatitis, pancreatic cancer, and several allergic reactions. However, the incidence is rare and depends on how long does trulicity stays in your system.

Foods to avoid with Trulicity

The right choice of food helps the body to respond well to trulicity and hence, is crucial. Trulicity diet plan involves eating more frequent but smaller meals throughout the day, choosing to eat more bland foods like crackers or toast, and avoiding some foods.

Let’s discuss some of the foods you should avoid while taking Trulicity.


Sweetened beverages are high in carbs and fructose which creates insulin resistance. Therefore, less insulin is absorbed into the blood. This leads to other metabolic changes such as increased cholesterol levels. And it in turn causes obesity.

Type 2 diabetes was known to have adult-onset but nowadays is seen in younger generations due to childhood obesity so this is raising concern.

White Foods

White bread, white pasta, white rice, or anything made from white flour are refined starches with a high glycemic index. Glycemic index is the ranking of carbs with regards to how much effect they have on sugar level.

foods to avoid with trulicity

Replace the white poisons with whole grains like high fiber cereals, brown wild rice, oatmeal, barley, etc. Whole grains are complex carbohydrates that digest slowly and have less effect on blood sugar.

Sweetened breakfast cereals

Breakfast cereals like corn flakes are often considered good for diabetes. However, most cereals are low in protein so if you’re buying cereals next time, make sure to get protein-based cereals to maintain your blood sugar level.

Flavored and sweetened yogurt

Flavored yogurts are loaded with sugars and carbs. Take unflavoured yogurts instead. However, in a moderate amount.

Coffee drinks

Black coffee is known to be good for the body so diabetic patients might not pay heed to the amount of coffee consumed. But trulicity and caffeine do not have a good tie.

Drinking coffee reduces the risk of developing diabetes but if you’re already suffering from diabetes, caffeine might alter your blood sugar level.

Even 2 cups of coffee will have that effect when you’re taking trulicity. It also raises the risk of developing diabetes mellitus complications. Hence, this is one of the most common but critical foods to avoid with trulicity.

“Healthy” alternatives of sugar

If you’re a diabetic and there’s one thing that you follow, I bet it is avoiding sugar. But if there’s one mistake you’re making, that is consuming too much of apparently healthy sugar alternatives. Honey, maple syrup, brown sugar all top the chart of alternatives.

You must realize that these may be natural sugars but they contain more carbohydrates than white sugar. So treat them with the same attention that white sugar gets and use them in moderation.

Otherwise, how much weight have you lost on trulicity will become a tough question to answer.

Packaged snacks

This might be the hardest to avoid in the entire list. I mean, come on, who doesn’t like some packaged goodness?

However, it is said that whatever tastes good is bad for your health. And unfortunately so, packaged goods are full of salt, sugar, white flour, preservatives, and mainly trans fat.

Dried fruits and fruit juices

Although it has fiber and minerals, dried fruits and fruit juices don’t fill up too much of your stomach. So, you might end up snacking too much. Always better to snack on raw fruits instead.

You can use this strategy for your trulicity for weight loss journey.

Red meat

Red and fatty meat contains saturated fats which increase cholesterol level and promotes inflammation. They also increase the risk of developing cardiovascular diseases.

Swap with lean proteins. Leans include poultry like chicken and turkey, egg without yolk, oily fish rich in omega 3 like salmon and mackerel, pulses like beans and lentils, and unsalted nuts.

Deep-fried food

The key to remember is “avoid CFCs”. Chips, cakes, chocolate, fries, fried chicken, and all that you have every time you go out to a restaurant should be pretty much avoided.

These are the most common foods to avoid with trulicity because they cause higher sugar levels for a longer duration of time as saturated fat takes longer to digest.

These foods are also fried in hydrogenated oil so they are high in trans fat. Easier said than done, these foods are not easy to avoid completely. So, try to make your versions at home using air fryers, grillers, or convection mode in your oven.


Trulicity and alcohol are both processed in the liver so when you’re drinking too much, there’s an overload on your liver.

A combination of the two can cause both hypoglycemia and hyperglycemia depending on how much you drink so limit your drinks and drink moderately.

Hypoglycemia occurs when your liver is blocked from releasing glycogen and the body’s mechanism to fight the “hypo” condition is blunted.

Doctors also recommend mixing diet soda or ice or calorie-free drinks with rum if needed because hard liquor has almost no carbs.

Full-fat dairy products

Full-fat dairy products are straight up yum but are high in saturated fats leading to insulin resistance. So, be aware!

Smoking and tobacco

The major content of cigarettes is nicotine which escalates blood sugar levels and causes insulin resistance so it’s best to quit smoking and avoid tobacco.

foods to avoid with trulicity

Although, when you’re trying to quit, make sure to slowly reduce smoking while closely monitoring your blood sugar level. Quitting at one go can imbalance your blood sugar level both ways.

Salted food

Salted foods can cause a rise in your blood pressure level increases the risk of heart diseases. Uncontrolled diabetes already takes a toll on your heart health so limit your salt intake to augment your heart health.


Trulicity works wonders in treating type 2 diabetes, one of the leading causes of morbidity and mortality across the world. Although there are no absolute restrictions on food, it is better to know about foods to avoid with trulicity to avoid its adverse effect.

As a diabetic patient, always remember, moderation is the key.


What is the best time for taking trulicity?

You can take trulicity every week at any time of the day with or without food using a trulicity pen for easier administration.

The half-life of trulicity is about 5 days and it takes 5 half-lives to eliminate the drug from the body so trulicity stays around 2-3 weeks in your body. However, the effect of the drug decreases with every half-life so it should be taken every 5 days or a week to be on the safe side.

Can trulicity be taken for weight loss?

Trulicity is not directly related to weight loss but people taking trulicity can lose some weight while on the drug. Nevertheless, the right dose is required for weight loss and the right dose varies for every individual.

According to a clinical trial, FDA approved two doses-

  • 3mg- an average weight loss of 8.8 pounds after 36 weeks
  • 4.5mg- an average weight loss of 10.4 pounds after 36 weeks.

Consult with your doctor to find the right dose.

Can trulicity and metformin be taken together?

Metformin is the first-line medication used to treat diabetes. It is safe to take metformin and trulicity together with your doctor’s approval.

Based on the longevity of the effects of metformin, the daily dose of metformin and a weekly dose of trulicity are usually prescribed. However, you must consult your doctor to know more about foods to avoid trulicity and metformin.

Arijah Nawar

Arijah Nawar

I’m a medical student from Bangladesh. If there’s one passion I count on, it’s writing. From a very young age I was moved by how writing encapsulates knowledge and has the power to inspire people. I hope to bring a change in people’s lives through my writings.

Wholesomealive.com -a blog about Healthy Living