Which Foods to Avoid with Trulicity?

The answer is as simple as it can be, “None.” You need not worry about what food you can eat if you’re diabetic and taking Trulicity. However, you need to moderate your diet. There’s no “NO” to any food. Just a little self-discipline will go a long way.

With self-discipline comes restraint and control. People must avoid some food items with Trulicity to amplify the drug’s effect. I’ll be going over 14 types of food to avoid when you’re on Trulicity. But, first, let’s get to know the drug better.

What is Trulicity?

Trulicity is not insulin. It’s an injectable drug that controls blood glucose levels with a low risk of hypoglycemia. Hypoglycemia is a common drawback for most glucose-reducing medicines but is not the case for Trulicity.

What is Trulicity?
Image credit: trulicity.com

Combined with diet and exercise, Trulicity can do wonders in treating “Type 2” diabetes. Additionally, it can reduce the risk of major cardiovascular diseases such as cardiac arrest and stroke. It also aids in weight loss.

Trulicity injection is given under the stomach, on our thighs, or upper. Remember, muscular areas quickly absorb the injection. Therefore, you need to inject it only once per week.

How Does Trulicity Work?

Trulicity or dulaglutide is a drug that enhances the activity of the GLP-1 receptor. This glucagon-like peptide is a natural human hormone.

How Does Trulicity Work?

It binds to the receptor present in the cells of the pancreas and helps release insulin from the pancreas. Increased activity of the receptor improves glycemic control by:

  • Decreasing glucagon secretion to reduce glucose production by the liver.
  • Reducing hunger pangs by slowing the emptying of gas in the intestines.
  • Increasing intracellular second messengers such as cAMP leading to glucose-dependent insulin release.
  • Stimulating natural production of insulin in the body.

Trulicity and Diabetes – The Relationship

Diabetes is a chronic ailment. It has reached an epidemic proportion among adults and children around the world. It is a disease that doctors often say affects from “the hair bulb to the toe finger.”

You’ll find two diabetic types among the affected. One where your body is not using insulin like it should (type 2 diabetes) and the other where your body is not making insulin or in an insufficient amount (type 1 diabetes).

foods to avoid with trulicity

Here’s the question, “Is trulicity effective against both types of diabetes?”

No. Trulicity is only effective against type 2 diabetes.

Treating type 2 diabetes requires the perfect balance of food, exercise, and medication. Trulicity is here to help.

Trulicity Complaints (Side Effects)

Common side effects of Trulicity include:

  • Stomach pain
  • Indigestion
  • Nausea
  • Diarrhea
  • Loss of appetite
  • Bomiting and
  • Bloating

About 10% of the people taking the drug complain of feeling “full”. Sometimes, they experience a sensation similar to that of overeating.

Other complaints include feeling enervated and exhausted. Let me be clear. Trulicity fatigue is real. It can make you feel sleepy all day as well. If you find yourself stuck to your bed 24/7, this drug is probably not the best thing to go for.

In the long run, Trulicity can trigger insulin resistance, AKA dulaglutide tolerance. Serious side effects of Trulicity include:

However, the incident is rare and depends on how long it stays in your system.

Coming to the Point: Foods to avoid with Trulicity

The right food choice helps the body respond well to the injection. Hence, it is crucial. Trulicity diet plan involves eating frequent but smaller meals throughout the day, eating more bland foods like crackers or toast, and avoiding some dishes, fruits, and other forms of diet.


Sweetened beverages are high in carbs and fructose. These create insulin resistance. As a result, our blood absorbs less and less insulin. This leads to metabolic changes such as increased cholesterol levels. In turn, it causes obesity.

In the past, Type-2 diabetes was known to have adult-onset. Nowadays, it is seen in younger generations due to childhood obesity, among other things. This is a rising concern.

Foods Made from White Flour or Refined Starch

White bread, pasta, rice, or anything made from white flour are refined starches with a high glycemic index. Glycemic index is the ranking of carbs depending on how many effects they have on sugar level.

foods to avoid with trulicity

Replace these with whole grains like high-fibre cereals, wild brown rice, oatmeal, barley, etc. Whole grains are complex carbohydrates. They digest slowly and have less effect on blood sugar.

Sweetened Breakfast Cereals

Breakfast cereals like corn flakes are often considered good for diabetes.

However, most cereals are low in protein. So next time you buy cereals, get protein-based ones to maintain your blood sugar level.

Flavored and (Especially Sweetened) Yogurt

Flavored yogurts are loaded with sugars and carbs. Consume unflavoured yogurts in a moderate amount instead.

Every Type of Coffee

Black coffee is known to be good for the body. Hence, diabetic patients might not regulate their coffee cravings. But Trulicity and caffeine don’t go well together.

Drinking coffee reduces the risk of diabetes. It’s true. But if you’re already suffering from the condition, caffeine might (and most probably will) alter your blood sugar level.

Two cups of coffee will have the same effect as Trulicity. However, too much coffee also raises the risk of developing diabetes mellitus. Hence, this is one of the most common but critical drinks to avoid with Trulicity. Caffeine addicts, I’m sorry!

“Healthy” Alternatives of Sugar

If you’re a diabetic and there’s one thing that you follow, I bet it’s avoiding sugar. But if there’s one mistake you’re making, that is consuming too many “Healthy” sugar alternatives. Honey, maple syrup, and brown sugar are on the list.

These may be natural sugar, but they contain more carbohydrates than we commonly have. So treat them with the same attention as white sugar and use them in moderation.

Otherwise, how much weight you have lost on Trulicity will be a tough question.

Packaged Snacks

This might be the hardest to avoid on the entire list. But, I mean, who doesn’t like some packaged goodness?

However, it is said that whatever tastes good is bad for your health.

Unfortunately, packaged goods contain salt, sugar, white flour, preservatives, and trans fat. Too much trans fat can trigger and worsen diabetes.

Dried Fruits and Fruit Juices

Although it has fiber and minerals, dried fruits and fruit juices don’t fill up too much of your stomach. So, you might end up snacking too much. Always better to snack on raw fruits instead.

You can use this strategy for your Trulicity for weight loss journey.

Red Meat

Red and fatty meat contains saturated fats, which increase cholesterol level and promote inflammation. They also increase the risk of developing cardiovascular diseases.

Swap with lean proteins. Leans include poultry like chicken and turkey, egg without yolk, oily fish rich in omega 3 like salmon and mackerel, pulses like beans and lentils, and unsalted nuts.

Deep-Fried Food

The key to remember is “Avoiding CFCs”. Chips, cakes, chocolate, fries, fried chicken, and all you have every time you go out to a restaurant should be pretty much avoided.

These things have saturated fat. As you might know, saturated fat takes longer to digest.

These foods are fried in hydrogenated oil as well. Hence, they are high in trans fat. These types of dishes aren’t easy to avoid, I know. So, try to make your own versions at home using air fryers, grillers, or convection mode in your oven.


Trulicity and alcohol are both processed in the liver. So, when you’re drinking too much, there’s an overload on your liver.

A combination of the two can cause hypoglycemia and hyperglycemia depending on how much you drink. So limit your drinks and drink moderately.

Hypoglycemia occurs when your liver stops releasing glycogen, and the body’s mechanism to fight the “Hypo” condition is blunted.

Doctors also recommend mixing diet soda, ice, or calorie-free drinks with rum because hard liquor has almost no carbs.

Full-fat dairy products

Full-fat dairy products are straight up yum but are high in saturated fats leading to insulin resistance. So, be aware!

Smoking and tobacco

The primary content of cigarettes is nicotine which escalates blood sugar levels and causes insulin resistance. Hence, it’s best to quit smoking and avoid tobacco.

foods to avoid with trulicity

Although, when you’re trying to quit, make sure to slowly reduce smoking while closely monitoring your blood sugar level. Stopping at one go can imbalance your blood sugar level both ways.

Salted food

Salted foods can cause a rise in your blood pressure level and increase the risk of heart disease. Uncontrolled diabetes already takes a toll on your heart health so limit your salt intake to augment your heart health.


  1. What Is the Best Time for Taking Trulicity?

You can take Trulicity every week at any time of the day with or without food using a Trulicity pen for easier administration.

The half-life of Trulicity is about 5 days, and it takes 5 half-lives to eliminate the drug from the body, so Trulicity stays around 2-3 weeks in your body. However, the drug’s effect decreases with every half-life, so it should be taken every 5 days or a week to be on the safe side.

  1. Can Trulicity Be Taken for Weight Loss?

Trulicity is not directly related to weight loss, but people taking Trulicity can lose some weight while on the drug. Nevertheless, the right dose is required for weight loss, and the right dose varies for every individual.

According to a clinical trial, FDA approved two doses-

  • 3mg- an average weight loss of 8.8 pounds after 36 weeks
  • 4.5mg- an average weight loss of 10.4 pounds after 36 weeks.

Consult with your doctor to find the right dose.

  1. Can Trulicity and Metformin Be Taken Together?

Metformin is the first-line medication used to treat diabetes. It is safe to take metformin and Trulicity with your doctor’s approval.

Based on the longevity of the effects of metformin, the daily dose of metformin and a weekly dose of Trulicity are usually prescribed. However, you must consult your doctor to know more about foods to avoid Trulicity and metformin.

Bottom Line

Trulicity works wonders in treating type 2 diabetes, one of the leading causes of morbidity and mortality worldwide.

Although there are no absolute restrictions on food, it is better to know about foods to avoid with trulicity to avoid its adverse effect.

As a diabetic patient, always remember that moderation is the key.

Arijah Nawar

Arijah Nawar

I’m a medical student from Bangladesh. If there’s one passion I count on, it’s writing. From a very young age I was moved by how writing encapsulates knowledge and has the power to inspire people. I hope to bring a change in people’s lives through my writings.

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